GASTRIN AND CHOLECYSTOKININ RECEPTOR LIGANDS

摘要

Compounds of formula (I) and their pharmaceutically acceptable salts are ligands at gastrin and/or cholecystokinin receptors. X and Y are independent ly =N-, -N(R5)- =CH-, -S- or -O-. n is from 1 to 4; R1 is H or C1 to C15 hydrocarbyl R2 is selected from H, Me, Et, Pr and OH, R3 is selected from H, Me, Et and Pr; or (when n is greater than 1) each R3 is independently select ed from H, Me, Et and Pr, or two R3 groups on neighbouring carbon atoms are linked to form a C3 to C6 carbocylic ring, or R2 and R3 on the same carbon atom together represent an =O group; R4 is C1 to C15 hydrocarbyl Z is -(NR7) a- CO-(NR8)b- (wherein a is 0 or 1, b is 0 or 1, -CO-NR7-CH2-CO-NR8-, -CO-O-, - CH2-CH2-, -CH=CH-, -CH2-NR8- or a bond; Q is -R9V, or (II), (wherein R9 is - CH2-; -CH2-CH2-; or (III), R9 and R8, together with the nitrogen atom to whi ch R8 is attached, form a piperidine or pyrrolidine ring which is substituted b y V; V is -CO-NH-SO2-Ph, -SO2-NH-CO-Ph, -CH2OH, or a group of the formula -R10 U, (wherein U is -COOH, tetrazolyl, -CONHOH- or -SO3H; and R10 is a bond; C1 to C6 hydrocarbylene, -O-(C1 to C3 alkylene)-; -SO2NR11-CHR12-; -CO-NR11-CHR12- , or -NH-(CO)c-CH2-, c being 0 or 1).