DELIVERY OF SUPEROXIDE DISMUTASE TO NEURONAL CELLS

摘要

A composition for delivery of superoxide dismutase to neuronal cells compris e a superoxide dismutase linked by a linker to a neuronal cell targeting component, which component comprises a first domain that binds to a neuronal cell and a second domain that translocates the superoxide dismutase into the neuronal cell. After translocation, the linker is cleaved to release superoxide dismutase from the neuronal cell targeting domain. Also described is use of the composition for treatment of oxidative damage to neuronal cell s and further targeting of the composition using human mitochondrial leader sequences. A hybrid polypeptide is described that contains a bacterial superoxide dismutase plus a sequence that targets a human mitochondria.