STIMULATION OF ANGIOGENESIS VIA SYNDECAN-4 CYTOPLASMIC DOMAIN SIGNALING PATHWAY

摘要

The present invention provides a methodology and compositions for stimulatin g angiogenesis in-situ within viable cells, tissues and organs comprising endothelial cells. The methodology focuses upon and controls the phosphorylation of the 183rd amino acid residue, serine within the cytoplasm ic domain and intracellular tail of transmembrane syndecan-4 proteoglycans whic h are then positioned at and through the cellular membrane of viable endotheli al cells. By intervening and maintaining the 183rd residue in a non- phosphorylated state, a consequential cascade of intracellular events is initiated which result in a stimulation of angiogenesis in-situ.