发明名称 |
TGF beta 1 responsive bone marrow derived cells to express a recombinant protein |
摘要 |
A method for expressing a recombinant protein from bone marrow-derived cells comprises the steps of treating the bone marrow-derived cells in vitro with a TGF beta 1 protein, which selects a population of the cells for further treatment. The selected cells can then be expanded, after which a gene encoding a therapeutic protein can be inserted into the expanded cells and thereafter express the therapeutic protein. The transduced cells can then be introduced into a mammal to produce a therapeutic result.
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申请公布号 |
US6063593(A) |
申请公布日期 |
2000.05.16 |
申请号 |
US19960747514 |
申请日期 |
1996.11.12 |
申请人 |
UNIVERSITY OF SOUTHERN CALIFORNIA UNIVERSITY PARK CAMPUS |
发明人 |
GORDON, ERLINDA MARIA;HALL, FREDERICK L.;ANDERSON, W. FRENCH |
分类号 |
C12N15/09;A61K31/711;A61K35/12;A61K35/28;A61K38/43;A61K48/00;C12N5/02;C12N5/0775;C12N5/10;C12P21/02;C12Q1/02;(IPC1-7):C12P21/06;C12P21/04 |
主分类号 |
C12N15/09 |
代理机构 |
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地址 |
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