Biological material for preparing pharmaceutical compositions for treating mammals

摘要

The invention concerns a biological material for preparing pharmaceutical compositions for treating mammals including either a nucleic acid sequence, containing at least a gene of therapeutic interest and elements expressing the gene in vivo in target cells genetically modified by one such nucleic sequence, or at least a target cell not producing antibodies naturally, genetically modified in vitro by at least one such nucleic acid sequence. The gene of therapeutic interest codes for all or part of an antibody expressed at the surface of the target cell, and such an antibody is capable of fixing itself to a polypeptide present at the surface of a cytotoxic effector cell or a T lymphocyte helper involved in the process activating such a cell.