ANZIOTENSIN II RECEIVING BODY BINDING INHIBITOR AND PREPARING METHOD THEREOF

摘要

PURPOSE: An angiotensin II receiving body binding inhibitor, which shows good inhibitive activity of the angiotensin II receiving body binding and good antagonistic action against vascular contraction induced by the angiotensin II, and a preparing method thereof are provided. CONSTITUTION: The angiotensin II receiving body binding inhibitor consists of a compound of following formula 1, where R represents aliphatic group having 5-20 carbon atoms, derivative thereof or salt thereof. The method comprises steps of: (i) extracting Evodiae Fructus with low class alcohol and then with acetate; and (ii) carrying out silica gel column chromatography, reverse phase low pressure column chromatography and high pressure liquid phase column chromatography on the extracted Evodiae Fructus. The pharmaceutical composition contains the compound of the formula 1 as an effective ingredient.