NOVEL CEPHALOSPHORINE ANTIBIOTICS

摘要

PURPOSE: A novel cephalosporin antibiotic product comprising the cephalosporin compound and other acceptable salts is provided for accomplishing excellent antibiotic activity to wide ranges of pathogenic bacteria including gram negative bacilli producing beta-lactamase and improved pharmaco-dynamic property. CONSTITUTION: The cephalosporin antibiotic product useful as antibiotic agent to pathogenic bacteria and having high pharmacological dynamic property comprises the cephalosporin compound of formula I (wherein R1 is hydrogen or amino protecting group; R2 and R3 are same or different and each represent hydrogen or hydroxy protecting groups or together form cyclic diol protecting group; R4 is hydrogen or carboxyl protecting group; R5, R6 and R7 are independently hydrogen, amino group or substituted amino, hydroxy or alkoxy group, C1-C4 alkyl group, carboxy or alkoxy carbonyl group, provided that R6 and R7 should form C3-C7 rings together with carbon atoms bonded to them; and Q is CH or N) and pharmaceutical acceptable and non-toxic salts, physiologically hydrolytic ester, hydrate and solvent and isomers thereof.