| 摘要 |
The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The present invention also provides methods for treating, preventing and/or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory drugs; treating and/or preventing gastrointestinal disorders; treating inflammatory disease states and disorders; and treating and/or preventing ophthalmic diseases or disorders.
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| 申请人 |
NITROMED, INC.;BANDARAGE, UPUL, K.;DONG, QING;FANG, XINQIN;GARVEY, DAVID, S.;MERCER, GREGORY, J.;RICHARDSON, STEWART, K.;SCHROEDER, JOSEPH, D.;WANG, TIANSHENG |
发明人 |
BANDARAGE, UPUL, K.;DONG, QING;FANG, XINQIN;GARVEY, DAVID, S.;MERCER, GREGORY, J.;RICHARDSON, STEWART, K.;SCHROEDER, JOSEPH, D.;WANG, TIANSHENG |
