| 摘要 |
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the structure (I) or a pharmaceutically acceptable salt thereof, wherein b is NY<1> or O; c is CY<2> or N; d is CY<3> or N; e is CY<4> or N; f is CY<5> or N; g is CY<6> or N; Y<4>, Y<5>, and Y<6> are independently hydrogen, C1-4 alkyl, or halogen; Y<1> and Y<2> are independently hydrogen, C1-4 alkyl, C3-7 cycloalkyl, halogen, NH2, OH or C1-4 alkoxy, and Y<3> is hydrogen, C1-4 alkyl, C3-7 cycloalkyl, halogen, -CN, NH2, OH or C1-4 alkoxy; A is (II), (III), (IV), (V) or (VI); and W, W<1>, R<1>, R<3>, R<4>, R<5>, X and Z are defined in the specification. |
| 申请人 |
MERCK & CO., INC.;BARROW, JAMES, C.;SANDERSON, PHILIP, E.;LYLE, TERRY, A.;DORSEY, BRUCE, D.;STANTON, MATTHEW, G.;STAAS, DONNETTE;COBURN, CRAIG;NAYLOR-OLSEN, ADEL, M.;MORRISSETTE, MATTHEW, M.;SELNICK, HAROLD, G.;NANTERMENT, PHILIPPE, G.;WILLIAMS, PETER, D.;STAUFFER, KENNETH, J.;BURGEY, CHRISTOPHER;ISAACS, RICHARD |
发明人 |
SANDERSON, PHILIP, E.;LYLE, TERRY, A.;DORSEY, BRUCE, D.;STANTON, MATTHEW, G.;STAAS, DONNETTE;COBURN, CRAIG;NAYLOR-OLSEN, ADEL, M.;MORRISSETTE, MATTHEW, M.;SELNICK, HAROLD, G.;NANTERMENT, PHILIPPE, G.;WILLIAMS, PETER, D.;STAUFFER, KENNETH, J.;BURGEY, CHRISTOPHER;ISAACS, RICHARD |
