| 摘要 |
PROBLEM TO BE SOLVED: To prepare solid preparations where a high molecular weight polymeric binder can be employed and the delayed release of an active ingredient is made possible by producing a plastic mixture of a specific polymeric binder, medicament active principle or the like under a specific condition and by molding the mixture so as to have a necessary dosage form. SOLUTION: The objective preparations are prepared by producing a plastic mixture of at least one kind selected from pharmaceutically acceptable polymeric binders having >75 K value (preferably homopolymer or a copolymer from vinylpyrrolidone) and at least one kind selected from medicament active principles, (e.g. ibuprofen or the like) and, optionally, a customary adjuvant under the condition of temperature (preferably <=250 deg.C) and shear energy input so as for K value difference showing the reduction in molecular weight of the binder to become <15 and by molding the mixture so as to have a necessary dosage form.
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