Neovascularization inhibitor containing tissue factor pathway inhibitor

摘要

PCT No. PCT/JP97/00973 Sec. 371 Date Sep. 10, 1998 Sec. 102(e) Date Sep. 10, 1998 PCT Filed Mar. 24, 1997 PCT Pub. No. WO97/35609 PCT Pub. Date Oct. 2, 1997There is provided an inhibitor of angiogenesis induced by growth of the vascular endothelial cells that comprises Tissue Factor Pathway Inhibitor (TFPI) as an active ingredient. The TFPI-containing preparation of the present invention can effectively inhibit angiogenesis induced by growth of the vascular endothelial cells, and thus, is quite efficacious for preventing and treating the conditions of diseases associated with angiogenesis such as malignant tumors.