| 摘要 |
The invention features methods for determining whether a patient is likely to develop agranulocytosis, for example, as a result of treatment with pharmaceutical agents that adversely affect leukocytes or their progenitors in the bone marrow. Further, it encompasses methods for screening compounds to find those useful in treating or preventing agranulocytosis, as well as methods for treating a patient who is at risk of developing, or who has developed, agranulocytosis. The invention is based, in part, on the identification of differentially expressed genes, i.e., genes that are either overexpressed or underexpressed in bone marrow cells treated with clozapine, the expression being relative to that in untreated bone marrow cells or in bone marrow cells that have been treated with a compound that does not alter expression of the differentially expressed genes of the invention (i.e., olanzapine). |
