A NOVEL MONOCLONAL ANTIBODY SPECIFIC FOR HIV-1 ENVELOPE PROTEIN GP41, ITS HYBRIDOMA CELL LINE AND PROCESS FOR PREPARATION THEREOF

摘要

PURPOSE: A monoclonal antibody against surface protein P41 of HIV-1 is provided which specifically recognizes surface protein gp41 of HIV-1. Therefore, it is used for developing diagnosis kit article of HIV-1 antigen and antibody so at to diagnose HIV-1 infection. CONSTITUTION: The monoclonal antibody specifically recognizes surface protein gp41 of HIV-1 in particular 584-618 amino acid sequence. The fusion cell line Kl 41(KCTC 0332 BP) is produced by: immunizing mouse with multiple antigenic peptide (MAP-1); fusing a spleen cell from immunized mouse with myeloma cell; and selecting monoclonal antibody producing fusion cell line.