| 发明名称 |
USE OF A CYTOKINE-PRODUCING LACTOCOCCUS STRAIN TO TREAT COLITIS |
| 摘要 |
The current invention relates to an administraton strategy for the delivery at the intestinal mucosa of cytokines or cytokine antagonists, preferably of acid sensitive anti-inflammatory agents, such as IL10 and/or soluble TNF receptor via the oral route. The prefered feature according to the invention is the inoculation with a suspension of recombinant Lactococcus lactis cells, which had been engineered to produce the respective proteins.
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| 申请公布号 |
WO0023471(A2) |
申请公布日期 |
2000.04.27 |
| 申请号 |
WO1999EP07800 |
申请日期 |
1999.10.06 |
| 申请人 |
VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW;STEIDLER, LOTHAR;REMAUT, ERIK, RENE;FIERS, WALTER |
发明人 |
STEIDLER, LOTHAR;REMAUT, ERIK, RENE;FIERS, WALTER |
| 分类号 |
C12N1/21;A61K35/74;A61K38/00;A61K38/17;A61K38/20;A61P1/04;A61P3/12;A61P7/06;A61P29/00;A61P43/00;C07K14/52;C07K14/54;C07K14/715;(IPC1-7):C07K14/54 |
主分类号 |
C12N1/21 |
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