| 摘要 |
<p>A solid support template for solid phase synthesis of amino group containing compounds is provided that comprises amino-ketone core compounds of the general formula: A-L-NH(CR1R2)nCOR3 linked to appropriate insoluble substrates to create solid support templates having the general formula: Polymer-X-L-NH(CR1R2)nCOR3 where L is a multifunctional monomer carrying a first functional group that forms a covalent bond with X and a second functional group comprising an amine and L, R1, R2 and R3 are selected from the group consisting of alkyl, alkyl-aryl, alkenyl, alkenyl-aryl groups having up to 6 carbon atoms and substituted forms thereof. The amino-ketones templates are useful for the solid phase synthesis of compounds such as the imidazoles, benzodiazepines, pyrazines, and steroid mimics.</p> |
