A novel approach to mitral or tricuspid valve repair involves the performance of an edge-to-edge fastening/securing of opposing heart valve leaflets (122, 124) through a catheter (126) entering the heart. Thus, a device is introduced including a leaflet fastener applicator through a cardiac catheter (126) or other suitable catheter. The leaflet fastener applicator and cardiac catheter (126) can be formed into a kit. A gripper (402) can be used to hold the heart valve leaflets (122, 124) while they are fastened.
