| 摘要 |
(57) The invention relates to a process for the preparation of a compound of formula (I): wherein, R1 represents C1-4 alkoxy; fluorine, chlorine or bromine; and R2 represents hydrogen or C1-4 alkoxy; which proces s comprises the reaction of the corresponding orthonitrohalobenzene of formula (II): wherein R1 and R2 are as hereinbefore defined and X represents a fluorine, chlorine or bromine atom, with, when X represents a fluorine atom: a) an alkali metal cyanide, in a non aqueous solvent optionally in the presence of a catalyst; or when X represents a chlorine atom: b) cuprous cyanide and a source of bromide selected from hydrogen bromide, bromine and a tetraalkylammonium bromide; optionally in the presence of an alkali metal bromide or an alkaline earth metal bromide; or c) an alkali metal cyanide or a tetraalkylammonium cyanide, in the presence of an alkali metal bromide or an alkaline earth metal bromide; or c) an alkali metal cyanide or a tetraalkylammonium cyanide, in the presence of cuprous bromide and a phase transfer catalyst; or d) cuprous cyanide and lithium iodide; or when X represents a bromine atom: e) cuprous cyanide optionally in the presence of a catalyst selected from an alkali metal bromide or an alkaline earth metal bromide; or f) an alkalie metal cyanide in thepresence of a catalytic amount of cuprous cyanide and a phase transfer catalyst. |
