| 摘要 |
<p>A polymer combining with phosphoric acid which has a true specific gravity of 1.18 to 1.24; a tablet containing particles of a polymer combining with phosphoric acid which have an average particle diameter of 400 νm or smaller, 90 % or more of which are accounted for by 500-νm or smaller particles, and which have a true specific gravity of 1.18 to 1.24 and a water content of 1 to 14 %, and optionally further containing crystalline cellulose and/or lowly substituted hydroxypropylcellulose; and a process for producing the tablet. The polymer, when used alone or optionally in combination with a specific additive, can provide an excellent preparation which has a high hardness, a high main-drug content, and the excellent ability to combine with phosphoric acid, rapidly disintegrates in an acidic to neutral region without being considerably affected by stirring strength, and can reduce the internal motion of the digestive tract and diminish bioavailability fluctuations caused by pH fluctuations.</p> |
