摘要 |
Disclosed are complexes of the NlK1 protein and proteins identified as interacting with the NlK1 protein (NlK1 protein-IPs). The NlK-1 interacting proteins include TrkA, protein phosphatase 1 alpha , 14-3-3 epsilon , alpha -tropomyosin, vimentin, p0071, Ini-1, and newly described proteins named IP-1, IP-2, IP-3, IP-4, and IP-5. Also described are derivatives, fragments analogs and homologs of these proteins. Methods of screening these complexes for efficacy in treating and/or preventing various diseases and disorders, particularly, neoplasia, neurodegenerative disease, hypertrophic cardiomyopathy, viral infections and metabolic diseases and disorders are also disclosed.
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申请人 |
CURAGEN CORPORATION;NANDABALAN, KRISHNAN;SCHULZ, VINCENT, P.;YANG, MEIJIA |
发明人 |
NANDABALAN, KRISHNAN;SCHULZ, VINCENT, P.;YANG, MEIJIA |