The invention relates to a method of treatment for a mammal in need of chemonucleolysis. The method comprising the administration of an effective proteoglycan cleaving amount of a proteoglycan-degrading enzyme and an effective amount of a growth factor effective in promoting the synthesis of a matrix component. The proteoglycan-degrading enzyme is preferably chondroitinase. The growth factor is preferably osteogenic protein. The proteoglycan-degrading enzyme and the growth factor are preferably administered simultaneously.
申请公布号
WO0020559(A1)
申请公布日期
2000.04.13
申请号
WO1999US17392
申请日期
1999.07.30
申请人
RUSH-PRESBYTERIAN-ST. LUKE'S MEDICAL CENTER
发明人
MASUDA, KOICHI;THONAR, EUGENE, J-M., A.;AN, HOWARD;SAMPATH, KUBER, T.