2,3-DISUBSTITUTED PYRIDINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, DRUG COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES FOR THE PREPARATION

摘要

Compounds represented by general formula (I) (wherein A is O, S, CHR<1> or NR<2>; R<1> and R<2> are each H or lower alkyl; X<1> and X<2> are each H, halogeno, nitro, cyano or the like; Y<1> is H or lower alkyl; Z<1> and Z<2> are each H, halogeno, cyano, hydroxy, lower alkyl or the like; and n is an integer of 2 to 4), and physiologically acceptable salts thereof; a process for the preparation of both; drug compositions containing the same as the active ingredient; and intermediates for the preparation. The compounds (I) exhibit potent PDE IV inhibiting and excellent bronchodilating activities, and are therefore useful as PDE IV inhibitors and as therapeutic and preventive drugs for various allergic inflammatory diseases, organ inflammatory diseases and so on, particularly airway-obstructive lung diseases including asthma.