| 摘要 |
PROBLEM TO BE SOLVED: To obtain a rapid disintegrative solid preparation which is rapidly disintegrated in the oral cavity, possesses a moderate strength in the production and distribution process and, in particular, is useful as an intraoral disintegrative solid preparation by including a medicinal ingredient, a saccharide and a specific low substituted bydroxypropyl cellulose. SOLUTION: This preparation is obtained by including (A) a medicinal ingredient (e.g. an antiulcer agent such as lansoprazole, voglibose, a drug for diabetes such as pioglitazone hydrochloride, manidipine hydrochloride, a hypotensive agent such as candesartan cilexetil, or the like), (B) a saccharide, preferably a sugar alcohol (e.g. erythritol, mannitol or the like), and (C) a low substituted hydroxypropyl cellulose which contains hydroxypropyl groups in an amount of 5-7 wt.% and possesses an average particle diameter of preferably 5-60μm. The components A, B and C are preferably included in proportions of 0.01-70 pts.wt., 5-97 pts.wt. and 3-50 pts.wt., respectively, based on 100 pts.wt. of the above preparation.
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