ETHERS OF 1-BENZYL-3-HYDROXYMETHYL-INDAZOLE WITH ALIPHATIC 2-HYDROXYACIDS

摘要

Compounds and methods of preparation of compounds with the formula A-CH2-O-CRR'-COOR"' (I) where A is a 1-benzyl-indazol-3-yl nucleus of the formula (see formula II) R and R' may be the same or different and are H or C1-C5 alkyl, R"' is H or the residue of an aliphatic saturated alcohol having from 1 to 4 carbon atoms; and, when R"' is H, the salts thereof with pharmaceutically acceptable bases. The addition of a methylene group (-CH2-) between the 1-benzyl-indazol-3yl nucleus and the side claim (-O-CH2-COOR"') endows the compounds of Formula (I) with analgesic activity.