发明名称 |
Methods of treating chronic pain |
摘要 |
This invention pertains to the surprising discovery of novel compositions and methods which selectively treat chronic pain while not significantly affecting basal nociceptive, acute pain, responses. The invention provides for compositions and methods of treating chronic pain by administering beta-endorphin-expressing recombinant expression systems such as adenovirus or adeno-associated virus into a subarachnoid or epidural space. The recombinant virus infects the pia mater connectve tissue cells and the infected cells express the fusion protein, wherein the fusion protein is secreted into the spinal cord parenchymal tissue in an amount effective to treat the chronic pain but not significantly affecting basal nociceptive responses. |
申请公布号 |
AU6151899(A) |
申请公布日期 |
2000.04.10 |
申请号 |
AU19990061518 |
申请日期 |
1999.09.17 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY |
发明人 |
MICHAEL J IADAROLA;ROBERT M. CAUDLE;ALAN A. FINEGOLD;ANDREW J. MANNES |
分类号 |
A61K35/76;A61K38/18;A61K38/33;A61K48/00;A61P25/04;C07K14/675 |
主分类号 |
A61K35/76 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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