| 摘要 |
<p>A medicine for treatment of diabetic nephropathy contains rhein or the salt thereof. It may be supplied in aqueous solution or capsula for oral, such dosage is not larger than 200mg/day. Toxicity of rhein or the salt thereof is low, LD50 is 3.2g/kg. The medicine concentration in blood is still higher in 24 hours after administered rhein by oral. Rhein could effectively control or decrease the hyperglycemia, suppress renal hypertrophy and kidney index in experimental diabetic rats. The urinary albumin execretion was significantly decreased in the diabetic patients treated by rhein.</p> |
