| 发明名称 |
RETROVIRAL PARTICLES PROTECTED AGAINST COMPLEMENT MEDIATED DESTRUCTION |
| 摘要 |
The present invention relates to retroviral particles which are specifically applicable as safe gene transfer vehicles for targeted gene therapy and which are protected against complement mediated destruction in host organisms. For producing such retroviral particles a packaging cell is provided according to the present invention comprising a DNA construct coding for one or more complement inhibitors. Said inhibitors are derived from the complement system of the organism to be infected by the retroviral particle generated by the packaging cell.
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| 申请公布号 |
WO0017374(A1) |
申请公布日期 |
2000.03.30 |
| 申请号 |
WO1999EP07083 |
申请日期 |
1999.09.23 |
| 申请人 |
BAVARIAN NORDIC RESEARCH INSTITUTE A/S;GUENZBURG, WALTER;SALMONS, BRIAN;BAUMANN, JOERG |
发明人 |
GUENZBURG, WALTER;SALMONS, BRIAN;BAUMANN, JOERG |
| 分类号 |
C12N15/09;A61K35/12;A61K35/76;A61K48/00;A61P31/12;A61P35/00;A61P43/00;C07K14/15;C12N5/10;C12N7/00;C12N15/12;C12N15/867;C12P21/02;C12R1/91;(IPC1-7):C12N15/86;C12N15/48;C12N7/01 |
主分类号 |
C12N15/09 |
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