发明名称 |
Methods and composition for detecting and treating kidney diseases associated with adhesion of crystals to kidney cells |
摘要 |
An autocrine crystal adhesion inhibitor called CAI is an anionic, sialic acid-containing glycoprotein secreted by kidney epithelial cells that blocks adhesion of calcium oxalate monohydrate (COM) crystals to the cell surface. Novel amino acid sequences are shown for the amino-acid terminus and 6 interval fragments. Persons may be classified according to risk of developing kidney stones, by measuring the amount of CAI in a biological sample. Treatment efficacy is also monitored by this method. CAI is administered in vivo to prevent nephrolithiasis. A rapid, simple assay to detect agents that inhibit adhesion of COM crystals to the surface of kidney epithelial cells is characterized.
|
申请公布号 |
US6043216(A) |
申请公布日期 |
2000.03.28 |
申请号 |
US19970837226 |
申请日期 |
1997.04.10 |
申请人 |
ARCH DEVELOPMENT CORPORATION |
发明人 |
TOBACK, F. GARY;LIESKE, JOHN C. |
分类号 |
A61K38/00;C07K14/47;C07K16/18;G01N33/50;G01N33/60;(IPC1-7):A61K38/17;C07K1/14 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|