发明名称 |
Sethod for the preparation of citalopram |
摘要 |
Preparation of citalopram (I) or its salt comprises reacting a isobenzofuran compound (IV) with (i) a cyanide source in the presence of a palladium catalyst and a catalytic amount of copper I or zinc II ions; or (ii) with zinc cyanide in the presence of a palladium catalyst; and isolating (I). - Preparation of citalopram of formula (I) comprises reacting an isobenzofuran compound of formula (IV) with (i) a cyanide source in the presence of a palladium catalyst and a catalytic amount of copper I or zinc II ions; or (ii) with zinc cyanide in the presence of a palladium catalyst; and isolating (I). - R = halo or CF3(CF2)nSO2; - n = 0-8. - An INDEPENDENT CLAIM is also included for (IV; R = CF3(CF2)nSO2 or iodo). |
申请公布号 |
AU1374500(A) |
申请公布日期 |
2000.03.27 |
申请号 |
AU20000013745 |
申请日期 |
1999.11.22 |
申请人 |
H. LUNDBECK, A/S |
发明人 |
HANS PETERSEN;MICHAEL HAROLD ROCK;HENRIK SVANE |
分类号 |
A61K31/343;A61P25/24;A61P29/00;C07B61/00;C07D307/81;C07D307/87 |
主分类号 |
A61K31/343 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|