Fucosyltransferases, polynucleotides encoding fucosyltransferases, and transgenic mammals incorporating same

摘要

This invention is biological in nature and relates to the synthesis, structure and biological activities of novel alpha-1,2 and alpha-1,3 fucosyltransferases from Caenorhabditis elegans ("C. elegans"). The present invention also contemplates a transgenic non-human eukaryotic mammal whose germ cells and somatic cells incorporate cDNA sequences encoding one or more of the novel alpha-1,2 and alpha-1,3 fucosyltransferases from C. elegans, introduced into the non-human eukaryotic mammal, or an ancestor of the non-human eukaryotic mammal, at an embyonic stage.