| 发明名称 |
STABLE COMPLEXES OF POORLY SOLUBLE COMPOUNDS |
| 摘要 |
Stable water-insoluble complexes of poorly soluble compounds molecularly dispersed in water-insoluble ionic polymers are disclosed. Useful insoluble ionic polymers have a molecular weight greater than about 80,000 D and a glass transition temperature equal to or greater than about 50.degree.. The compounds are microprecipitated in the ionic polymers in amorphous form. The complexes according to the present invention significantly increase the bioavailability of poorly soluble therapeutically active compounds.
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| 申请公布号 |
CA2282906(A1) |
申请公布日期 |
2000.03.22 |
| 申请号 |
CA19992282906 |
申请日期 |
1999.09.20 |
| 申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
PHUAPRADIT, WANTANEE;ALBANO, ANTONIO A.;SANDHU, HARPREET K.;SHAH, NAVNIT HARGOVINDAS |
| 分类号 |
C07D239/60;A61K9/14;A61K9/20;A61K9/48;A61K31/15;A61K31/166;A61K31/18;A61K31/216;A61K31/404;A61K31/496;A61K31/515;A61K31/5517;A61K45/08;A61K47/30;A61K47/32;A61K47/38;A61K47/48;C07D403/14;C07D487/04;(IPC1-7):C07D403/14;C08B11/04;C08B3/16;C08B11/193;C07C231/22;C08F8/32;C07C303/42;C07C311/49;C07D239/62;A61K31/715;A61K31/78;A61K31/785;C07C233/81 |
主分类号 |
C07D239/60 |
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