发明名称 |
ALKYL, AZIDO, ALKOXY, AND FLUORO-SUBSTITUTED AND FUSED QUINOXALINEDIONES AND THE USE THEREOF AS GLYCINE RECEPTOR ANTAGONISTS |
摘要 |
Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia, and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, and Down's syndrome, treating or preventing the adverse consequences of the hyperactivity of the excitatory amino acids, as well as treating anxiety, chronic pain, convulsions, and inducing anesthesia are disclosed by administering to an animal in need of such treatment an alkyl or azido-substituted 1,4-dihydroquinoxaline-2,3-dione or pharmaceutically acceptable salts thereof, which have high binding to the glycine receptor. |
申请公布号 |
EP0732942(A4) |
申请公布日期 |
2000.03.22 |
申请号 |
EP19950902458 |
申请日期 |
1994.11.07 |
申请人 |
COCENSYS, INC.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;STATE OF OREGON |
发明人 |
CAI, SUI, XIONG;WEBER, ECKARD;KEANA, JOHN, F., W.;KHER, SUNIL |
分类号 |
A61K31/495;A61K51/04;A61P3/08;A61P9/10;A61P25/00;A61P43/00;C07D241/38;C07D241/44;C07D487/04;C07D491/04 |
主分类号 |
A61K31/495 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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