发明名称 |
NOVEL INDOLE DERIVATIVES USEFUL TO TREAT ESTROGEN-RELATED NEOPLASMS AND DISORDERS |
摘要 |
The present invention relates to novel indole derivatives of formula (I), useful in down-regulating estrogen receptor expression. Also included are methods for the treatment of neoplasms or of controlling the growth of a neoplasm in a patient afflicted with a neoplastic disease, espe- <IMG> cially estrogen-dependent neoplasms (I) such as those associated with breast, ovarian and cervical tissue. Another embodiment of the present invention is a method of prophylactically treating a patient at risk of developing neoplastic disease state. Also provided is a method for treating autoimmune diseases. Also included are pharmaceutical compositions of the novel indole derivatives.
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申请公布号 |
CA2183731(C) |
申请公布日期 |
2000.03.21 |
申请号 |
CA19952183731 |
申请日期 |
1995.01.31 |
申请人 |
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发明人 |
BITONTI, ALAN J.;MCDONALD, IAN A.;SALITURO, FRANCESCO G.;WHITTEN, JEFFREY P.;JARVI, ESA T.;WRIGHT, PAUL S. |
分类号 |
A61K31/40;A61K31/403;A61K31/404;A61K31/405;A61P35/00;A61P35/02;C07D209/18;C07D209/22;C07D209/24;C07D209/26;C07D209/28;C07D209/42;(IPC1-7):C07D209/18;A61K31/445;A61K31/495;A61K31/535 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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