ANTIBODIES TO THE ED-B DOMAIN OF FIBRONECTIN, CONJUGATES CONTAINING THEM AND USE THEREFOR FOR DIAGNOSIS AND THERAPY OF TUMORS AND DISEASES ASSOCIATED WITH ANGIOGENESIS

摘要

The present invention relates to antibodies with sub-nanomolar affinity specific for a characteristic epitope of the ED-B domain of fibronectin, a marker of angiogenesis. Furthermore, it relates to the use of radiolabeled high affinity anti ED-B antibodies for detecting new-forming blood vessels in vivo and a diagnostic kit comprising said antibody. Furthermore, it relates to conjugates comprising said antibodies and suitable photoactive molecules (e.g. a judiciously chosen photosensitizer), and their use for the selective light-mediated occlusion of new blood vesels.