| 摘要 |
The present invention relates to compounds of general formula (I), wherein R 1 is tetrahydronaphtyl; or -(CH2)n-C6H5-R4 wherein n is 0-4 and R4 is H, lower alkyl, or lower alkoxy; or C5-C12 cycloalkyl, optionally substituted by lowe r alkyl; R2 is H, OH, lower alkoxy, lower alkenyloxy or lower alkyl; R3 is C5- C7 cycloalkyl or phenyl, optionally substituted by OH, halogen, lower alkoxy, lower alkenyloxy, lower alkyl or -O-(CH2)n-C6H5 wherein n is 0-3; and their pharmaceutically acceptable acid addition salts. The compounds of general formula (I) are suitable for the treatment of memory and attention deficits, psychiatric, neurological and physiological disorders, such as anxiety and stress disorders, depression, memory loss due to Alzheimer's disease or othe r dementias such as vascular dementia and AIDS dementia complex, Parkinson's disease, epilepsy and convulsions, acute and/or chronic pain conditions, withdrawal symptoms of addictive drugs and reduction of their abuse/craving, control of water balance, Na+ excretion, arterial blood pressure disorders a nd metabolic disorders such as obesity.
|
