| 发明名称 |
THE ADDITION OF OXYGEN NUCLEOPHILES TO VINYL EPOXIDES |
| 摘要 |
Nucleophilic oxygen species, such as primary alcohols, carboxylates, and water, are added to vinyl epoxides in a highly regioselective and enantioselective manner, providing a convenient route to enantiomerically enriched 2,2-diols and oxygen-containing heterocycles. The reaction employs a chireal Pd(0) complex and a borane or borate as co-catalysts. Also described are similar additions of nitrogen nucleophils, and the addition of carbonates to vinyl epoxides using a chiral Pd(0) catalyst.
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| 申请公布号 |
WO0014033(A1) |
申请公布日期 |
2000.03.16 |
| 申请号 |
WO1999GB02973 |
申请日期 |
1999.09.08 |
| 申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;CHIROTECH TECHNOLOGY LIMITED |
发明人 |
TROST, BARRY, MARTIN;MCEACHERN, ERNEST, JOHN;TOSTE, FRANCISCO, DEAN |
| 分类号 |
C07B53/00;C07C41/03;C07D307/28;C07D309/24;C07D313/04;C07D317/12;C07D317/38;(IPC1-7):C07B53/00 |
主分类号 |
C07B53/00 |
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