The invention relates to insulin analogs exhibiting enhanced zinc binding capacity and to stable zinc complexes thereof having a retarded activity in comparison with human insulin. The invention further relates to a method for the production of said insulin analogs and to their use, particularly in pharmaceutical preparations for therapy of type I and type II diabetes mellitus.
申请公布号
WO9964598(A3)
申请公布日期
2000.03.16
申请号
WO1999EP03490
申请日期
1999.05.21
申请人
AVENTIS PHARMA DEUTSCHLAND GMBH;ERTL, JOHANN;HABERMANN, PAUL;GEISEN, KARL;SEIPKE, GERHARD;WOLLMER, AXEL
发明人
ERTL, JOHANN;HABERMANN, PAUL;GEISEN, KARL;SEIPKE, GERHARD;WOLLMER, AXEL