Chiral synthesis of 2-hydroxy carboxylic acids with a dehydrogenase

摘要

PCT No. PCT/EP95/02692 Sec. 371 Date May 29, 1997 Sec. 102(e) Date May 29, 1997 PCT Filed Jul. 7, 1995 PCT Pub. No. WO96/01892 PCT Pub. Date Jan. 25, 1996Inter alia, an enzyme, a 2-hydroxy carboxylic acid dehydrogenase, characterised in that it is obtainable from Lactobacillus delbrueckii ssp. Bulgaricus and in that it catalyses the production of (R)-hydroxy derivatives of 2-keto acids, which are unsubstituted in the 3-position, but which may be substituted in the 4-position or beyond is disclosed.