DNA ASSAY FOR THE PREDICTION OF AUTOIMMUNE DIABETES

摘要

The present invention relates to a novel DNA assay for the diagnosis and/or prediction of autoimmune diabetes. The present invention relates to a DNA assay for the prediction of autoimmune diabetes in human subjects, which comprises the steps of a) obtaining a DNA sample from the subject and PCR amplification of class III alleles of variable number of tandem repeats (VNTR) located upstream of the insulin gene (INS); and b) electrophoretic co-migration of amplified fragment to identify class III alleles of the insulin VNTR which are identical to S1 or S2, from alleles which differ from S1 and S2; whereby identification of S1 or S2 allele is indicative of at least 1% risk of autoimmune diabetes.