摘要 |
A novel cytokine, designated Apo-2 ligand, which induces mammalian cancer cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to Apo-2 ligand are also provided. Methods of using Apo-2 ligand to induce apoptosis and to treat pathological conditions such as cancer, are further provided.
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申请人 |
GENENTECH, INC.;ASHKENAZI, AVI, J.;KELLEY, ROBERT, F.;O'CONNEL, MARK, T.;PITTI, ROBERT, M.;SCHWALL, RALPH, H. |
发明人 |
ASHKENAZI, AVI, J.;KELLEY, ROBERT, F.;O'CONNEL, MARK, T.;PITTI, ROBERT, M.;SCHWALL, RALPH, H. |