USE OF SUPPRESSOR tRNA'S TO REGULATE CYTOTOXICITY DURING THE PRODUCTION OF RECOMBINANT GENE PRODUCTS
摘要
A method for regulating the expression of a toxic protein in a cell destined to produce a recombinant gene product is disclosed. The method relies on the introduction of a termination codon into the coding sequence of the toxic protein and complementation with a suppressor tRNA.
申请公布号
WO0011154(A1)
申请公布日期
2000.03.02
申请号
WO1999US16726
申请日期
1999.08.20
申请人
CELL GENESYS, INC.;DONAHUE, BRIAN, A.;HARDY, STEPHEN, F.;SNYDER, RICHARD, O.
发明人
DONAHUE, BRIAN, A.;HARDY, STEPHEN, F.;SNYDER, RICHARD, O.