| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new protein GMP30 which has a specific amino acid sequence, has an inflammation-regulating activity, and can be used, for example, as a medicine such as an antiinflammatory agent, and for developing such a medicine, because the protein is derived from a monocyte, and his an inflammation-regulating activity. SOLUTION: This is a new protein GMP30 which has the amino acid sequence shown by the formula, or an amino acid sequence which is obtained by deleting, substituting, inserting, or adding one or more amino acid(s) from/in/into/to the sequence shown by the formula, has an inflammation-regulating activity, and can be used, for example, directly as a medicine such as an antiinflammatory agent, and indirectly, for example, for screening medicines. Because the protein has an inflammation-regulating activity. This protein is obtained by isolating mRNA from a human peripheral blood monocyte, preparing a cDNA library using the obtained mRNA, screening the obtained library using its partial sequence as a probe, inserting the obtained gene to an appropriate vector, transfecting the obtained vector into a host cell for transformation, followed by culturing the obtained transformant. |
