发明名称 |
Gastrointestinal bacterial antibody factories |
摘要 |
Neonates during their first thirty days of life are particularly susceptible to pathogens because their immune system is not yet fully functional. Adults may also be unusually susceptible to pathogens when their immune system has been compromised by disease or when they have been acutely exposed to a bolus of GI pathogen. The invention provides a method of immunizing neonates and adults to pathogens by orally administering recombinant probiotic bacteria that express antibodies to the pathogens. These recombinant bacteria may be optionally administered with antibodies immunologically specific to the pathogens. The invention further provides a composition of recombinant probiotic bacteria that express antibodies to pathogen, and a method to use this composition to immunize neonates and adults. |
申请公布号 |
AU5328599(A) |
申请公布日期 |
2000.02.21 |
申请号 |
AU19990053285 |
申请日期 |
1999.07.29 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION. |
发明人 |
WILLIAM E. FAHL;GEOFFREY J. LETCHWORTH;GERALD C. MUELLER;ADAM K. SAVAGE;DEBORAH LOO |
分类号 |
C12N15/09;A61K35/74;A61K39/07;A61K39/108;A61K39/395;A61K48/00;A61P1/00;A61P31/04;A61P31/12;C07K16/10;C12N1/21;C12R1/225 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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