| 摘要 |
The present invention provides eukaryotic cells capable of replicating recombinant expression vectors that produce heterologous proteins, wherein the cell comprises a polynucleotide encoding a repressor protein that is capable of repressing production of the heterologous protein. The invention also provides recombinant vectors, such as viruses (for example, adenoviruses) comprising (i) a first polynucleotide sequence encoding a heterologous protein and (ii) a second polynucleotide sequence operably linked to the first polynucleotide in order to permit repression of the expression of the first polynucleotide gene. |
