SESTERTERPENE DERIVATIVES EXHIBITING ANTIFUNGAL ACTIVITIES

摘要

Compounds represented by general formula (I); and pharmaceutically acceptabl e salts or esters thereof, (wherein Y1 is oxygen, NH, O-CO, O-SO2, O-CO-NH, O- CS- NH, NH-CO, NH-SO2, NH-CO-NH or NH-CS-NH; and R1 is alkyl, alkenyl, alkynyl, aryl, aralkyl, arylalkenyl, arylalkynyl, cycloalkyl, cycloalkylalkyl, alkylcarbonyl, alkoxycarbonyl, arylcarbonyl or a heterocyclic group, provide d these groups may be optionally substituted). The above compounds, salts and esters exert excellent antifungal effects on fungi against which the existin g antifungal agents are not sufficiently efficacious, thus being useful as antifungal agents.