发明名称 |
IMMUNOLOGICAL HERPES SIMPLEX VIRUS ANTIGENS AND METHODS FOR USE THEREOF |
摘要 |
The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by T-cells derived from herpetic lesions or from uterine cervix. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved antiviral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection. |
申请公布号 |
WO0008051(A2) |
申请公布日期 |
2000.02.17 |
申请号 |
WO1999US17803 |
申请日期 |
1999.08.05 |
申请人 |
UNIVERSITY OF WASHINGTON |
发明人 |
KOELLE, DAVID, M.;COREY, LAWRENCE |
分类号 |
C12N15/09;A61K31/711;A61K35/76;A61K38/00;A61K39/00;A61P31/22;C07K14/035;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N7/00;C12N7/01;C12N15/34;C12N15/38;C12P21/02;C12R1/91;C12R1/93;(IPC1-7):C07K14/00 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|