A mutant herpesvirus in which (a) an early gene encoding a function required for expression of late gene products has been inactivated, e.g. by deletion; and in which (b) a viral gene essential for production of infectious new virus particles has been inactivated, preferably by deletion; and in which (c) a gene to be delivered to a target cell has been inserted together with regulatory elements for its expression in a target cell, can be used as a gene delivery vector for gene delivery e.g. to central nervous system cells.
申请公布号
WO0008192(A2)
申请公布日期
2000.02.17
申请号
WO1999GB02538
申请日期
1999.08.02
申请人
CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED;EFSTATHIOU, STACEY;LACHMANN, ROBIN, HENRY;SCARPINI, CINZIA, GIUSEPPINA