| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject inhibitor comprising a hydroxypyridone derivative (salt), having an excellent inhibitory effect on discoloration and change in color of gingiva and lips of an unhealthy color and safety to in vivo tissue. SOLUTION: This inhibitor comprises a hydroxy-2-pyridone derivative of the formula (R1 and R2 are each H or-OH and at least one of R1 and R2 is OH; R3 to R5 are each H or a monofunctional organic group). The derivative of the formula has a tautomer. In the case of 1-hydroxy-2-pyridone skeleton, 2-hydroxypyridine-N-Oxide skeleton, etc., exist as an isomer, in the case of 3-hydroxy-2-pyridone skeleton, 2,3-dihydroxypyrine skeleton, etc., exist and the derivative contains these isomers. The amount of the derivative (salt) of the formula formulated is 0.001-20 wt.%, preferably 0.01-10 wt.%, more preferably 0.1-5 wt.%.
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