发明名称 |
ANTI-TUMOUR COMPOUNDS CONTAINING QUINAZOLINE AND TETRAZOLE RINGS |
摘要 |
<p>The invention relates to quinazoline derivatives, or pharmaceutically-acceptable salts thereof, which possess anti-tumour activity; to processes for their manufacture; and to pharmaceutical compositions containing them. The invention provides a quinazoline of the formula: wherein R1 is (1-4C)alkyl; the quinazoline ring may optionally bear one or two further substituents selected from halogeno, (1-4C)alkyl and (1-4C)alkoxy; R2 is hydrogen or (1-4C)alkyl; R3 includes hydrogen and (1-4C)alkyl; and Ar is optionally substituted phenylene or heterocyclene; or a pharmaceutically-acceptable salt or ester thereof.</p> |
申请公布号 |
CA2090942(C) |
申请公布日期 |
2000.02.08 |
申请号 |
CA19932090942 |
申请日期 |
1993.03.03 |
申请人 |
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发明人 |
PEGG, STEPHEN JOHN;WARDLEWORTH, JAMES MICHAEL |
分类号 |
A61K31/505;A61K31/495;A61K31/517;A61P35/00;C07D239/88;C07D239/95;C07D257/04;C07D401/14;C07D403/12;(IPC1-7):C07D403/12;C07D417/14;C07D409/14 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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