CONTINUOUS PROCESS FOR PREPARING OPTICALLY PURE (S)-3,4-DIHYDROXYBUTYRIC ACID DERIVATIVES

摘要

The present invention relates to a continuous process for preparing opticall y pure (S)-3,4-dihydroxybutyric acid derivatives expressed by Formula (1) and more particularly, to the continuous process which enables preparing optical ly pure (S)-3,4-dihydroxybutyric acid derivatives economically in large quantities, by: (a) preparing .alpha.-(1,4) linked oligosaccharide having adequate sugar distribution by reacting amylopectin which is easily availabl e from natural product with enzyme under a specific condition; and (b) performing oxidation by running basic anion exchange resin with an oxidant t o give (S)-3,4-dihydroxybutyric acid-anion exchange resin complex, dissociatin g the (S)-3,4-dihydroxybutyric acid from anion exchange resin complex and esterification sequentially under a specific condition. In Formula (1), R represents linear or branched alkyl group with 15 carbon atoms.