发明名称 |
Crystal of a protein-ligand complex containing an N-terminal truncated eIF4E, and methods of use thereof |
摘要 |
A detailed three-dimensional structure for the least abundant of the general translation initiation factors in eukaryotes, eIF4E, complexed with a ligand is disclosed. The novel N-terminal truncated eIF4Es which were constructed so as to omit a significant portion of the flexible N-terminal tail of the eIF4E are also part of the present invention. In addition, the crystals of the protein-ligand complexes containing the N-terminal truncated eIF4Es are also included. Furthermore, methods of identifying antagonists of the eIF4E protein which can be used to regulate protein synthesis in cells are also disclosed.
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申请公布号 |
US6020162(A) |
申请公布日期 |
2000.02.01 |
申请号 |
US19980097233 |
申请日期 |
1998.06.12 |
申请人 |
THE ROCKEFELLER UNIVERSITY;MCGILL UNIVERSITY |
发明人 |
BURLEY, STEPHEN K.;SONENBERG, NAHUM;MARCOTRIGIANO, JOSEPH;GINGRAS, ANNE-CLAUDE |
分类号 |
C07K14/47;(IPC1-7):C12N15/63 |
主分类号 |
C07K14/47 |
代理机构 |
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地址 |
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